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So if you are feeling lost this is the article you should be reading…read on
then.
What Are Selective Serotonin Reuptake
Inhibitors?
They are also referred to as serotonin specific reuptake inhibitors. What they
are, is a group of compounds basically utilized as a form of antidepressant. Antidepressants are
used to treat cases of depression, some forms of personality disorders and cases of disorders
related to anxiety; they have also been known to treat some case of lack of sleep
(insomnia). It
should be noted that SSRIS are by far the highest prescribed drugs used to deal with depression in
a lot of countries.
Activity Of SSRIS
It is a wide spread notion that they improve the activity at the extracellular
state within the neurotransmitter serotonin through inhibiting the reuptake
going within the presynaptic cell compounding the amount of serotonin within the synaptic cleft
made possible to attach on the postsynaptic receptor. They consist of different levels of
selectivity for the other monoamine transporters with selective serotonin reuptake inhibitors
possessing a not so strong affinity for the noradrenalin and dopamine transporter. In lemans terms
they work on the brain. So with selective serotonin reuptake inhibitors SSRIS
comparisons the comprehensive one is the one with the highest normal brain function
assistance.
Characteristics Of SSRIS
· In contrast with one of the selective serotonin reuptake inhibitors SSRIS
comparisons with placebos; the degree or size of the gains of antidepressant forms of medication
when looked at against those of placebos may be seen to be very low or not existing on average,
when looking at patients with non server or mild symptoms. But for cases where the signs are server
and apparent, the advantages of medication over placebo are substantial.
-
SSRIS where discovered through a
process calledrational drug design(it is
different from the typical process of drug discovery which entails a process of
trial and error , basically the process involves the creation of a hypothesis,
that modulation of a particular biological specimen may have some form of
therapeutic value).
-
They are the initial group of
psychotropic drugs to be discovered through this process.
-
SSRI is basically a misnomer created
by the health and pharmaceutical organizations that created these drugs. They are also
referred to as dopamine reuptake inhibitors and nonrepinephrine reuptake inhibitors
(DRIs and NRis).
Comparisons Of The Different Types Of
SSRIS
1. Citalopram : it’s an anti depressant belonging to the group of the SSRIS. It has received USAs
FDA (Food and drug administration) approval to assist in treating cases of major depression and in
some cases of anxiety it is prescribed off label.
2. Dapoxetine : known to be a short acting form of SSRI, portrayed as a solution for premature
ejaculation in males. It is the only drug known yet with a form of regulatory approval for such a
case. It has received approval from several European countries as of yet and is within phase three
of the FDAs process of approval.
3. Zimelidine: This is the initial or first antidepressant medication to be put on shelf’s and
marketed. Its structure is a varying one from other typical anti depressants. After being developed
in the 1980s and fist being sold in 1982; it has since been banned across the globe. It was
discovered to cause serious and in some cases fatal cases of central and or peripheral neuropathy
known as Guillian Barre syndrome and the increase of sensitivity to hypersensitivity reaction,
which entailed a lot of organs such the skin exanthema, arthralgias, eosinophilia and sometimes flu
like symptoms.
It also was discovered to increase suicide tendencies among depressed
patients.
4. VIlazodone: It was developed through the use of clinical data which was acquired
for the treatment of serious cases of depressive disorders. It had received phase three approval
from its clinical trials in 2009. It has received approval from the FDA to be used in the US to
treat serious cases of depression.
In an eight week random trial it was noted that within the first week it gave an
antidepressant result. After the eight weeks patients treated with the drug showed a relatively
higher response rate than those who were given the control which was the placebo. It should also be
noted that it also has a rate of sexual disadvantages and weight gain as well when compared to a
placebo.
Others to look up are Paroxetine, Sertraline , indalpine, luvoxamine, fluoxetine
and Escitalopram but due to time and space constraints cannot be discussed in detail
here.
In one of the selective serotonin reuptake inhibitors SSRIS comparisons
between placebos, it was concluded that SSRIS were more reliable ad effective than the placebos for
treatment of OCD (Obsessive compulsive disorder) within the short term, although they were varying
aspects between the unfavorable effects of different kinds of SSRIS. Their longer term
comprehensiveness was yet to be concluded for the treatment of OCD. For a more detailed analysis of
this study go to, Cochrane
Collaboration. There was also
another study conducted for the comparison of moclobemide with SSRIS on the sexual performance
in depressed adults conducted by German and Australian study. Click
here.
I
hope this article has shed some light on the issue of the different selective serotonin reuptake
inhibitors SSRIS comparisons and it will assist you in making an informed decision on choosing the
right SSRIS.
Summary
-
Are drugs used to treat depression and
case of OCD
-
Some have been discovered to have
adverse effects on sexual performance and weight
-
Study have shown their effectiveness
in the short term but more studies have yet to be conducted on their long term
effectiveness
-
The differences on their effectiveness
between placebos are minor to nonexistent for minor cases of depression: but for severe
cases their assistance is recognizable
You can get your hands on some published articles and books both hard covers and
soft copies for yourkindle or ipad @ Amazon.com. A couple would
be:
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The
clinical use of citalopram, fluoxetine, fluvoxamine, paroxetine and Sertraline by J.P
Feighner and W.F buyer going for about $46.00
To get your hands on the prescribed drugs go to Drugstore.com forcitalopram and other SSRIS: on this site all that
you are required to do is type in the name of the drug you require and follow the easy to
understand steps. It is advisable to contact your physician before making any form of
purchase.
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