|
,
and its presence was noticed within ten years of its discovery in the contract nervous system of
animals and for a neurotransmitter function e.g. 108. The evidence of the
5th receptor
heterogeneity was found by late 1950. In 1979 two distinct populations of 5-HT binding sites
wereidentified in rat brains and in the periphery 5-HT 1 and 5-HT2
sites.
The 5-HT 1 sites were mixed
serotonin receptors known 5-hydroxytryptamine receptors; these are the cell surface proteins that
combine serotonin and activate intercellular changes which control the performance of the cells. It
has been recognized that a number of serotonin receptors differ in their pharmacology, molecular
biology and more of action. Check out Pharmacologycorner.com for an
explanation a high school grad can make sense of.
Types of Serotonin Receptors
They are divided into 7 from
5-HT1A-7 will give a brief information . 5-HT1A
Receptors :
this is a very important type that deals with a number of functions that will include memory,
depression, fear and anxiety. Medications that target the 5-HT1A receptor are largely used to
modulate pathological manifestation of the mentioned functions. 5-HTA2A: Are expressed drugs that
activate the 5-HT2A receptors are often hallucinogens. Several other hallucinogenic drugs
exist and their affinity for binding to the 5-HT2A receptor predictor predicts their potency
to produce hallucinogenic effects in humans. There are many other types of receptors but due
to space we cannot mention them here. Click
here
Location of Serotonin Receptors
Serotonin receptors are located
in many different places. A wonderful way has been examined to locate and orientate the five
serotonin 1a agonists in singles factor model lipid and brain lipid membranes. The agonist
positions are searched by monitoring changes in the lipid proton chemical shifts and by
MAS-assisted unclear. In the sole component bilayer the membrane agonist is mostly found
predominately at the crown of the hydrophobic series of the membrane. The largest parts the
agonists orient more or less parallel to the membrane plane with the exception of the quipazine,
which is originates in the glycerol region, while the benzene is positioned in the lipid
hydrophobic series.
Cognitive Behavior ofthe Receptor
The serotonergic system appears
to play a role in behaviors that involve a high cognitive demand and in memory improvement or
recovery from impaired cognitive performance as made evidence after
an administration of serotonin. These serotonin receptors are localized in cognitive pathways
with the hippocampus and frontal cortex as the main target structures. Understanding the role
played by these and other serotonin receptors subtypes in cognition is likely to result from the
recent availability of new molecular tools.
There is a lot that have been
mentioned about serotonin receptors that I believe it has become very useful to you. Take your time
and read more on the topic and be well versed on the terms that are used. The article has given out
the types of serotonin receptors.
Summary
-
Its been over seventy years now since
serotonin was revealed
-
-
A number of serotonin receptors have
been recognized that they differ in their pharmacology, molecular biology and mode of
action and
-
The serotonergic
system appears to play a role in behaviors that involve a high cognitive demand and
in memory improvement
Additional information
|
Digg
Diigo
Facebook
Stumbleupon
Twitter
Google Bookmarks